Sulforaphane modulates TGFβ2-induced conjunctival fibroblasts activation and fibrosis by inhibiting PI3K/Akt signaling

AIM: To examine the effects of sulforaphane on fibrotic changes of transforming growth factor (TGFβ2) induced human conjunctival fibroblast (HConFs). METHODS: HConFs were cultured and divided into control, TGFβ2 (1 ng/mL), sulforaphane and TGFβ2+sulforaphane groups. Cell viability and apoptosis wer...

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Bibliographic Details
Main Authors: Han-Ruo Liu, Zi-Yao Xia, Ning-Li Wang
Format: Article
Language:English
Published: Press of International Journal of Ophthalmology (IJO PRESS) 2020-10-01
Series:International Journal of Ophthalmology
Subjects:
Online Access:http://www.ijo.cn/en_publish/2020/10/20201001.pdf