Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

Matrine Reverses the Warburg Effect and Suppresses Colon Cancer Cell Growth via Negatively Regulating HIF-1α

The Warburg effect is a peculiar feature of cancer’s metabolism, which is an attractive therapeutic target that could aim tumor cells while sparing normal tissue. Matrine is an alkaloid extracted from the herb root of a traditional Chinese medicine, Sophora flavescens Ait. Matrine has been reported...

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Bibliographic Details
Main Authors: Xiaoting Hong, Linhai Zhong, Yurou Xie, Kaifeng Zheng, Jinglong Pang, Yesen Li, Yifan Yang, Xiaolin Xu, Panying Mi, Hanwei Cao, Wenqing Zhang, Tianhui Hu, Gang Song, Daxuan Wang, Yan-yan Zhan
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Pharmacology
Subjects:
matrine
HIF-1α
Warburg effect
colon cancer
glucose metabolism
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01437/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01437/full

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