Arterial levels of oxygen stimulate intimal hyperplasia in human saphenous veins via a ROS-dependent mechanism.

Saphenous veins used as arterial grafts are exposed to arterial levels of oxygen partial pressure (pO2), which are much greater than what they experience in their native environment. The object of this study is to determine the impact of exposing human saphenous veins to arterial pO2. Saphenous vein...

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Bibliographic Details
Main Authors: Binata Joddar, Michael S Firstenberg, Rashmeet K Reen, Saradhadevi Varadharaj, Mahmood Khan, Rachel C Childers, Jay L Zweier, Keith J Gooch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4370681?pdf=render