Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees

Germline variation networks in the PI3K/AKT pathway corresponding to familial high-incidence lung cancer pedigrees

Abstract Background There were scarcely germline variants of familial lung cancer (LC) identified. We conducted an study with whole-exome sequencing of pedigrees with familial lung cancer to analyze the potential genetic susceptibility. Methods Probands with the highest hereditary background were id...

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Bibliographic Details
Main Authors: Huan Lin, Gong Zhang, Xu-chao Zhang, Xin-lei Lian, Wen-zhao Zhong, Jian Su, Shi-liang Chen, Yi-long Wu
Format: Article
Language:English
Published: BMC 2020-12-01
Series:BMC Cancer
Subjects:
PI3K/AKT pathway
Familial lung cancer
Germline variation networks
Whole-exome sequencing
Online Access:https://doi.org/10.1186/s12885-020-07528-3

Internet

https://doi.org/10.1186/s12885-020-07528-3

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