Single molecule FRET reveals pore size and opening mechanism of a mechano-sensitive ion channel

The mechanosensitive channel of large conductance, which serves as a model system for mechanosensitive channels, has previously been crystallized in the closed form, but not in the open form. Ensemble measurements and electrophysiological sieving experiments show that the open-diameter of the channe...

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Bibliographic Details
Main Authors: Yong Wang, Yanxin Liu, Hannah A DeBerg, Takeshi Nomura, Melinda Tonks Hoffman, Paul R Rohde, Klaus Schulten, Boris Martinac, Paul R Selvin
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2014-02-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/01834