Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6’)-Im

Aminoglycoside resistance profile and structural architecture of the aminoglycoside acetyltransferase AAC(6’)-Im

Aminoglycoside 6’-acetyltransferase-Im (AAC(6’)-Im) is the closest monofunctional homolog of the AAC(6’)-Ie acetyltransferase of the bifunctional enzyme AAC(6’)-Ie/APH(2”)-Ia. The AAC(6’)-Im acetyltransferase confers 4- to 64-fold higher MICs to 4,6-disubstituted aminoglycosides and the 4,5-disubsti...

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Bibliographic Details
Main Authors: Clyde A. Smith, Monolekha Bhattacharya, Marta Toth, Nichole K. Stewart, Sergei B. Vakulenko
Format: Article
Language:English
Published: Shared Science Publishers OG 2017-11-01
Series:Microbial Cell
Subjects:
antibiotic resistance
aminoglycosides
acetyltransferase
crystal structure
Online Access:http://microbialcell.com/researcharticles/aminoglycoside-resistance-profile-and-structural-architecture-of-the-aminoglycoside-acetyltransferase-aac6-im/

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http://microbialcell.com/researcharticles/aminoglycoside-resistance-profile-and-structural-architecture-of-the-aminoglycoside-acetyltransferase-aac6-im/

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