Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity

Isomerization of Asp7 in Beta-Amyloid Enhances Inhibition of the α7 Nicotinic Receptor and Promotes Neurotoxicity

Cholinergic dysfunction in Alzheimer’s disease (AD) can be mediated by the neuronal α7 nicotinic acetylcholine receptor (α7nAChR). Beta-amyloid peptide (Aβ) binds to the α7nAChR, disrupting the receptor’s function and causing neurotoxicity. In...

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Bibliographic Details
Main Authors: Evgeny P. Barykin, Alexandra I. Garifulina, Elena V. Kruykova, Ekaterina N. Spirova, Anastasia A. Anashkina, Alexei A. Adzhubei, Irina V. Shelukhina, Igor E. Kasheverov, Vladimir A. Mitkevich, Sergey A. Kozin, Michael Hollmann, Victor I. Tsetlin, Alexander A. Makarov
Format: Article
Language:English
Published: MDPI AG 2019-07-01
Series:Cells
Subjects:
amyloid-beta
nicotinic acetylcholine receptor
modifications
Alzheimer’s disease
neurotoxicity
calcium imaging
radioligand analysis
aspartate isomerization
Online Access:https://www.mdpi.com/2073-4409/8/8/771

Internet

https://www.mdpi.com/2073-4409/8/8/771

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