Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection

Synovial Fluid Interleukin-16 Contributes to Osteoclast Activation and Bone Loss through the JNK/NFATc1 Signaling Cascade in Patients with Periprosthetic Joint Infection

Because of lipopolysaccharide (LPS)-mediated effects on osteoclast differentiation and bone loss, periprosthetic joint infection (PJI) caused by Gram-negative bacteria increases the risk of aseptic loosening after reimplantation. Synovial fluid interleukin-16 (IL-16) expression was higher in patient...

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Bibliographic Details
Main Authors: Yuhan Chang, Yi-min Hsiao, Chih-Chien Hu, Chih-Hsiang Chang, Cai-Yan Li, Steve W. N. Ueng, Mei-Feng Chen
Format: Article
Language:English
Published: MDPI AG 2020-04-01
Series:International Journal of Molecular Sciences
Subjects:
synovial fluid
interleukin-16
periprosthetic joint infection
osteoclast
bone loss
c-Jun N-terminal kinase
Online Access:https://www.mdpi.com/1422-0067/21/8/2904

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https://www.mdpi.com/1422-0067/21/8/2904

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