Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer’s Disease

Palmitoylethanolamide Counteracts Enteric Inflammation and Bowel Motor Dysfunctions in a Mouse Model of Alzheimer’s Disease

Palmitoylethanolamide (PEA), an endogenous lipid mediator, is emerging as a promising pharmacological agent in multiple neurodegenerative disorders for its anti-inflammatory and neuroprotective properties. However, its effects on enteric inflammation and colonic dysmotility associated with Alzheimer...

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Bibliographic Details
Main Authors: Vanessa D’Antongiovanni, Carolina Pellegrini, Luca Antonioli, Laura Benvenuti, Clelia Di Salvo, Lorenzo Flori, Rebecca Piccarducci, Simona Daniele, Alma Martelli, Vincenzo Calderone, Claudia Martini, Matteo Fornai
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-09-01
Series:Frontiers in Pharmacology
Subjects:
alzheimer’s disease
colonic dysmotility
enteric glial cells
enteric gliosis
intestinal inflammation
palmitoylethanolamide
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.748021/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2021.748021/full

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