Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

Increasing intratumor C/EBP-β LIP and nitric oxide levels overcome resistance to doxorubicin in triple negative breast cancer

Abstract Background Triple negative breast cancer (TNBC) easily develops resistance to the first-line drug doxorubicin, because of the high levels of the drug efflux transporter P-glycoprotein (Pgp) and the activation of pro-survival pathways dependent on endoplasmic reticulum (ER). Interfering with...

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Bibliographic Details
Main Authors: Iris C. Salaroglio, Elena Gazzano, Ahmad Abdullrahman, Eleonora Mungo, Barbara Castella, Gamal Eldein Fathy Abd-ellatef Abd-elrahman, Massimo Massaia, Massimo Donadelli, Menachem Rubinstein, Chiara Riganti, Joanna Kopecka
Format: Article
Language:English
Published: BMC 2018-11-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
Triple negative breast cancer
Doxorubicin
P-glycoprotein
Endoplasmic reticulum stress
CAAT/enhancer binding protein (C/EBP)-β
Calreticulin
Online Access:http://link.springer.com/article/10.1186/s13046-018-0967-0

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http://link.springer.com/article/10.1186/s13046-018-0967-0

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