Differing von Hippel Lindau genotype in paired primary and metastatic tumors in patients with clear cell renal cell carcinoma

Differing von Hippel Lindau genotype in paired primary and metastatic tumors in patients with clear cell renal cell carcinoma

In sporadic clear cell renal cell carcinoma (CCRCC), the von Hippel Lindau (VHL) gene is inactivated by mutation or methylation in the majority of primary (P) tumors. Due to differing effects of wild-type (WT) and mutant (MT) VHL gene on downstream signaling pathways regulating angiogenesis, VHL gen...

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Bibliographic Details
Main Authors: Susan A.J. Vaziri, Emmanuel J Tavares, Ali R Golshayan, Brian I Rini, Hakan eAydin, Ming eZhou, Linda eSercia, Laura eWood, Mahrukh K Ganapathi, Ronald M Bukowski, Ram eGanapathi
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-05-01
Series:Frontiers in Oncology
Subjects:
Genetic Heterogeneity
VHL genotype
renal cancer
Online Access:http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00051/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fonc.2012.00051/full

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