RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

RECQL4 Promotes DNA End Resection in Repair of DNA Double-Strand Breaks

The RecQ helicase RECQL4, mutated in Rothmund-Thomson syndrome, regulates genome stability, aging, and cancer. Here, we identify a crucial role for RECQL4 in DNA end resection, which is the initial and an essential step of homologous recombination (HR)-dependent DNA double-strand break repair (DSBR)...

Full description

Bibliographic Details
Main Authors: Huiming Lu, Raghavendra A. Shamanna, Guido Keijzers, Roopesh Anand, Lene Juel Rasmussen, Petr Cejka, Deborah L. Croteau, Vilhelm A. Bohr
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
RECQL4
Rothmund-Thomson syndrome
DNA resection
homologous recombination
DNA repair
RecQ-like helicase
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716306921

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716306921

Similar Items