A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

A Small Molecule Stabilizer of the MYC G4-Quadruplex Induces Endoplasmic Reticulum Stress, Senescence and Pyroptosis in Multiple Myeloma

New approaches to target MYC include the stabilization of a guanine-rich, G-quadruplex (G4) tertiary DNA structure in the NHE III region of its promoter. Recent screening of a small molecule microarray platform identified a benzofuran, D089, that can stabilize the MYC G4 and inhibit its transcriptio...

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Bibliographic Details
Main Authors: Snehal M. Gaikwad, Zaw Phyo, Anaisa Quintanilla Arteaga, Sayeh Gorjifard, David R. Calabrese, Daniel Connors, Jing Huang, Aleksandra M. Michalowski, Shuling Zhang, Zheng-Gang Liu, John S. Schneekloth, Beverly A. Mock
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cancers
Subjects:
MYC G4-quadruplex stabilizer
endoplasmic reticulum stress
senescence
pyroptosis
inflammasome
caspase 1
Online Access:https://www.mdpi.com/2072-6694/12/10/2952

Internet

https://www.mdpi.com/2072-6694/12/10/2952

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