Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with impairment of cognition, memory deficits and behavioral abnormalities. Accumulation of amyloid beta (Aβ) is a characteristic hallmark of AD. Microglia express several GPCRs, which, upon activation by modulators, med...

Full description

Bibliographic Details
Main Authors: Md. Ezazul Haque, In-Su Kim, Md. Jakaria, Mahbuba Akther, Dong-Kug Choi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-08-01
Series:Frontiers in Cellular Neuroscience
Subjects:
GPCR
microglia
Alzheimer’s disease
amyloid beta
acetylcholine receptors
adrenergic receptors
Online Access:https://www.frontiersin.org/article/10.3389/fncel.2018.00258/full

Internet

https://www.frontiersin.org/article/10.3389/fncel.2018.00258/full

Similar Items