Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Importance of GPCR-Mediated Microglial Activation in Alzheimer’s Disease

Alzheimer’s disease (AD) is a progressive neurodegenerative disorder associated with impairment of cognition, memory deficits and behavioral abnormalities. Accumulation of amyloid beta (Aβ) is a characteristic hallmark of AD. Microglia express several GPCRs, which, upon activation by modulators, med...

Full description

Bibliographic Details
Main Authors:	Md. Ezazul Haque, In-Su Kim, Md. Jakaria, Mahbuba Akther, Dong-Kug Choi
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2018-08-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	GPCR microglia Alzheimer’s disease amyloid beta acetylcholine receptors adrenergic receptors
Online Access:	https://www.frontiersin.org/article/10.3389/fncel.2018.00258/full

Similar Items

Inflammation, microglia, and alzheimer's disease
by: Brent Cameron, et al.
Published: (2010-03-01)

Phagocytic functions of microglial cells in the central nervous system and their importance in two neurodegenerative diseases: multiple sclerosis and Alzheimer’s disease
by: Choucair Nada, et al.
Published: (2006-12-01)

Identification of a dysfunctional microglial population in human Alzheimer’s disease cortex using novel single-cell histology image analysis
by: Molly E. V. Swanson, et al.
Published: (2020-10-01)

Roles of Microglial and Monocyte Chemokines and Their Receptors in Regulating Alzheimer's Disease-Associated Amyloid-β and Tau Pathologies
by: Joana R. Guedes, et al.
Published: (2018-08-01)

Aging and Progression of Beta-Amyloid Pathology in Alzheimer’s Disease Correlates with Microglial Heme-Oxygenase-1 Overexpression
by: Cristina Fernández-Mendívil, et al.
Published: (2020-07-01)

Microglial Turnover in Ageing-Related Neurodegeneration: Therapeutic Avenue to Intervene in Disease Progression
by: Shofiul Azam, et al.
Published: (2021-01-01)

Immune cell responses to amyloid-beta proteins: What is the extent and implications of amyloid-beta induced cytotoxicity in microglial cells and peripheral blood mononuclear cells?
by: Cao, A.
Published: (2017-07-01)

Inhibition of formyl peptide receptors improves the outcome in a mouse model of Alzheimer disease
by: Nicole Schröder, et al.
Published: (2020-04-01)

What can we learn from molecular dynamics simulations for GPCR drug design?
by: Christofer S. Tautermann, et al.
Published: (2015-01-01)

HHV-6A infection induces amyloid-beta expression and activation of microglial cells
by: Daria Bortolotti, et al.
Published: (2019-12-01)

Spreading of Beta-Amyloid in Organotypic Mouse Brain Slices and Microglial Elimination and Effects on Cholinergic Neurons
by: Kurt Moelgg, et al.
Published: (2021-03-01)

The Cholinergic System, the Adrenergic System and the Neuropathology of Alzheimer’s Disease
by: Rola A. Bekdash
Published: (2021-01-01)

Involvement of exchange protein directly activated by cAMP and tumor progression locus 2 in IL-1β production in microglial cells following activation of β-adrenergic receptors
by: Hidetoshi Tozaki-Saitoh, et al.
Published: (2020-07-01)

Beta-adrenergic receptor antagonism is proinflammatory and exacerbates neuroinflammation in a mouse model of Alzheimer's Disease
by: Andrew K. Evans, et al.
Published: (2020-12-01)

Mitochondrial Regulation of Microglial Immunometabolism in Alzheimer’s Disease
by: Lauren H. Fairley, et al.
Published: (2021-02-01)

Cryo-EM structures of the β3 adrenergic receptor bound to solabegron and isoproterenol
by: Demura, K., et al.
Published: (2022)

Editorial: The Role of Glia in Alzheimer's Disease
by: Beatriz G. Pérez-Nievas, et al.
Published: (2019-01-01)

Microglia function in Alzheimer’s disease
by: Egle eSolito, et al.
Published: (2012-02-01)

GPR4 Knockout Improves the Neurotoxin-Induced, Caspase-Dependent Mitochondrial Apoptosis of the Dopaminergic Neuronal Cell
by: Md Ezazul Haque, et al.
Published: (2020-10-01)

Ligands of Adrenergic Receptors: A Structural Point of View
by: Yiran Wu, et al.
Published: (2021-06-01)

The Dual Role of Kinin/Kinin Receptors System in Alzheimer’s Disease
by: Bingyuan Ji, et al.
Published: (2019-10-01)

Involvement of the Sigma-1 Receptor in Neuronal Cell Death and Alzheimer's Disease
by: Raymond, Sophie Olivia
Published: (2021)

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s disease
by: David J. Braun, et al.
Published: (2020-09-01)

G-Protein-Coupled Receptors in CNS: A Potential Therapeutic Target for Intervention in Neurodegenerative Disorders and Associated Cognitive Deficits
by: Shofiul Azam, et al.
Published: (2020-02-01)

Early long-term administration of the CSF1R inhibitor PLX3397 ablates microglia and reduces accumulation of intraneuronal amyloid, neuritic plaque deposition and pre-fibrillar oligomers in 5XFAD mouse model of Alzheimer’s disease
by: Justyna Sosna, et al.
Published: (2018-03-01)

The Role of NMDA Receptors in Alzheimer’s Disease
by: Jinping Liu, et al.
Published: (2019-02-01)

CALCIUM-SENSING RECEPTORS OF HUMAN NEURAL CELLS PLAY CRUCIAL ROLES IN ALZHEIMER’S DISEASE
by: Anna eChiarini, et al.
Published: (2016-04-01)

A Novel Targeted and High‐Efficiency Nanosystem for Combinational Therapy for Alzheimer's Disease
by: Han Yang, et al.
Published: (2020-10-01)

Revisiting the Idea That Amyloid-β Peptide Acts as an Agonist for P2X7
by: Lučka Bibič, et al.
Published: (2020-09-01)

ALPHA7 NICOTINIC ACETYLCHOLINE RECEPTOR REGULATION IN EXPERIMENTAL NEURODEGENERATIVE DISEASE
by: Charriez, Christina Margaret
Published: (2010)

Exploring the Role of P2X Receptors in Alzheimer’s Disease
by: Pamela Andrea Godoy, et al.
Published: (2019-11-01)

APOE genotype and sex affect microglial interactions with plaques in Alzheimer’s disease mice
by: T. L. Stephen, et al.
Published: (2019-05-01)

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis
by: Alfonso Grimaldi, et al.
Published: (2019-09-01)

Dysfunctional Mitochondria and Mitophagy as Drivers of Alzheimer’s Disease Pathogenesis
by: Anushka Chakravorty, et al.
Published: (2019-11-01)

Microglia in the Alzheimer's brain: a help or a hindrance?
by: Craig T. Vollert, et al.
Published: (2014-12-01)

Alzheimer's-associated PU.1 expression levels regulate microglial inflammatory response
by: Anna A. Pimenova, et al.
Published: (2021-01-01)

The Neuroprotective Effects of GPR4 Inhibition through the Attenuation of Caspase Mediated Apoptotic Cell Death in an MPTP Induced Mouse Model of Parkinson’s Disease
by: Md Ezazul Haque, et al.
Published: (2021-04-01)

DEER Analysis of GPCR Conformational Heterogeneity
by: Matthias Elgeti, et al.
Published: (2021-05-01)

Investigation of adrenoceptor genes (β2 & β3) in women with polycystic ovary syndrome
by: Farideh Zafari Zangeneh, et al.
Published: (2018-12-01)

Alzheimer’s disease as an inflammatory disease
by: Bolós Marta, et al.
Published: (2017-03-01)