An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency.

The DNA mismatch repair system (MMR) maintains genome stability through recognition and repair of single-base mismatches and small insertion-deletion loops. Inactivation of the MMR pathway causes microsatellite instability and the accumulation of genomic mutations that can cause or contribute to can...

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Bibliographic Details
Main Authors: Julie M Bailis, Marcia L Gordon, Jesse L Gurgel, Alexis C Komor, Jacqueline K Barton, Ilan R Kirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3812133?pdf=render