An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency.

An inducible, isogenic cancer cell line system for targeting the state of mismatch repair deficiency.

The DNA mismatch repair system (MMR) maintains genome stability through recognition and repair of single-base mismatches and small insertion-deletion loops. Inactivation of the MMR pathway causes microsatellite instability and the accumulation of genomic mutations that can cause or contribute to can...

Full description

Bibliographic Details
Main Authors: Julie M Bailis, Marcia L Gordon, Jesse L Gurgel, Alexis C Komor, Jacqueline K Barton, Ilan R Kirsch
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3812133?pdf=render

Similar Items

Similar Items