CTG trinucleotide repeat "big jumps": large expansions, small mice.

CTG trinucleotide repeat "big jumps": large expansions, small mice.

Trinucleotide repeat expansions are the genetic cause of numerous human diseases, including fragile X mental retardation, Huntington disease, and myotonic dystrophy type 1. Disease severity and age of onset are critically linked to expansion size. Previous mouse models of repeat instability have not...

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Bibliographic Details
Main Authors: Mário Gomes-Pereira, Laurent Foiry, Annie Nicole, Aline Huguet, Claudine Junien, Arnold Munnich, Geneviève Gourdon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC1847694?pdf=render

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http://europepmc.org/articles/PMC1847694?pdf=render

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