Silencing I2PP2A rescues tau pathologies and memory deficits through rescuing PP2A and inhibiting GSK-3β signaling in human tau transgenic mice

Silencing I2PP2A rescues tau pathologies and memory deficits through rescuing PP2A and inhibiting GSK-3β signaling in human tau transgenic mice

Increase of inhibitor-2 of protein phosphatase-2A (I2PP2A) is associated with PP2A inhibition and tau hyperphosphorylation in Alzheimer’s disease (AD). Down-regulating I2PP2A attenuated amyloidogenesis and improved the cognitive functions in transgenic mice expressing amyloid precursor protein (tg25...

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Bibliographic Details
Main Authors: Yao eZhang, Rong-Hong eMa, Xia-Chun eLi, Jia-Yu eZhang, Hai-Rong eShi, Wei eWei, Dan-Ju eLuo, Qun eWang, Jian-Zhi eWang, Gong-Ping eLiu
Format: Article
Language:English
Published: Frontiers Media S.A. 2014-06-01
Series:Frontiers in Aging Neuroscience
Subjects:
Alzheimer Disease
Memory
tau hyperphosphorylation
inhibitor-2 of protein phosphatase-2A
glycogen synthase kinase 3β
Online Access:http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00123/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fnagi.2014.00123/full

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