Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress

Metformin reduces ovarian ischemia reperfusion injury in rats by improving oxidative/nitrosative stress

Objective: To assess the preventive role of metformin on rat ovarian ischemia reperfusion injury. Materials and methods: Forty rats were divided equally into five groups; Group 1: sham, Group 2: surgical control with 3-hr torsion and detorsion, Group 3: 50 mg/kg p.o. metformin 30 min before 3-hr tor...

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Bibliographic Details
Main Authors: Mustafa Demir, Bulent Yilmaz, Senol Kalyoncu, Meltem Tuncer, Zehra Bozdag, Onur Ince, Mehmet Akif Bozdayi, Hasan Ulusal, Seyithan Taysi
Format: Article
Language:English
Published: Elsevier 2021-01-01
Series:Taiwanese Journal of Obstetrics & Gynecology
Subjects:
Ischemia reperfusion injury
Rat ovarian torsion
Metformin
Oxidative stress index
Peroxynitrite
Online Access:http://www.sciencedirect.com/science/article/pii/S1028455920302539

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http://www.sciencedirect.com/science/article/pii/S1028455920302539

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