LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats

LPS-Induced Systemic Neonatal Inflammation: Blockage of P2X7R by BBG Decreases Mortality on Rat Pups and Oxidative Stress in Hippocampus of Adult Rats

Neonatal lipopolysaccharide (LPS) exposure-induced brain inflammation has been associated to neuronal injury and facilitates the development of models of neurological disorders in adult rats. The P2X7 receptor (P2X7R) plays a fundamental role in the onset and maintenance of the inflammatory cascade....

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Bibliographic Details
Main Authors: Clivandir Severino da Silva, Michele Longoni Calió, Amanda Cristina Mosini, Jaime Moreira Pires, Débora da Silva Bandeira Rêgo, Luiz E. Mello, Ana Teresa Figueiredo Stochero Leslie
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-11-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
P2X7 receptor
brilliant blue G
lipopolysaccharide
neonate
inflammation
nervous system
Online Access:https://www.frontiersin.org/article/10.3389/fnbeh.2019.00240/full

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https://www.frontiersin.org/article/10.3389/fnbeh.2019.00240/full

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