SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.

SARS-CoV 9b protein diffuses into nucleus, undergoes active Crm1 mediated nucleocytoplasmic export and triggers apoptosis when retained in the nucleus.

BACKGROUND: 9b is an accessory protein of the SARS-CoV. It is a small protein of 98 amino acids and its structure has been solved recently. 9b is known to localize in the extra-nuclear region and has been postulated to possess a nuclear export signal (NES), however the role of NES in 9b functioning...

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Bibliographic Details
Main Authors: Kulbhushan Sharma, Sara Åkerström, Anuj Kumar Sharma, Vincent T K Chow, Shumein Teow, Bernard Abrenica, Stephanie A Booth, Timothy F Booth, Ali Mirazimi, Sunil K Lal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3103500?pdf=render

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http://europepmc.org/articles/PMC3103500?pdf=render

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