Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms

Integration of GPCR Signaling and Sorting from Very Early Endosomes via Opposing APPL1 Mechanisms

Summary: Endocytic trafficking is a critical mechanism for cells to decode complex signaling pathways, including those activated by G-protein-coupled receptors (GPCRs). Heterogeneity in the endosomal network enables GPCR activity to be spatially restricted between early endosomes (EEs) and the recen...

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Bibliographic Details
Main Authors: Silvia Sposini, Frederic G. Jean-Alphonse, Mohammed A. Ayoub, Affiong Oqua, Camilla West, Stuart Lavery, Jan J. Brosens, Eric Reiter, Aylin C. Hanyaloglu
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717316431

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http://www.sciencedirect.com/science/article/pii/S2211124717316431

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