Emergence of a STAT3 mutated NK clone in LGL leukemia

Emergence of a STAT3 mutated NK clone in LGL leukemia

Large granular lymphocyte (LGL) leukemia is a chronic clonal lymphoproliferative disorder. Here, a T-LGL leukemia patient developed NK-LGL leukemia with residual leukemic T-LGL. TCRVβ usage and CDR3 sequence drifts were observed with disease progression. A STAT3 S614R mutation was identified in NK b...

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Bibliographic Details
Main Authors: Yiyi Yan, Thomas L. Olson, Susan B. Nyland, David J. Feith, Thomas P. Loughran Jr.
Format: Article
Language:English
Published: Elsevier 2015-01-01
Series:Leukemia Research Reports
Subjects:
Clonal evolution
T cell receptor
Classifications
Mutation detection
Leukemia markers
Online Access:http://www.sciencedirect.com/science/article/pii/S2213048914000247

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http://www.sciencedirect.com/science/article/pii/S2213048914000247

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