Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles

Rational design for controlled release of Dicer-substrate siRNA harbored in phi29 pRNA-based nanoparticles

Small interfering RNA (siRNA) for silencing genes and treating disease has been a dream since ranking as a top Breakthrough of the Year in 2002 by Science. With the recent FDA approval of four siRNA-based drugs, the potential of RNA therapeutics to become the third milestone in pharmaceutical drug d...

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Bibliographic Details
Main Authors: Daniel W. Binzel, Songchuan Guo, Hongran Yin, Tae Jin Lee, Shujun Liu, Dan Shu, Peixuan Guo
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
RNA nanotechnology
dicer processing
gene regulation
siRNA delivery
exosomes
nanobiotechnology
Online Access:http://www.sciencedirect.com/science/article/pii/S216225312100189X

Internet

http://www.sciencedirect.com/science/article/pii/S216225312100189X

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