Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling

Cancer cell growth and survival as a system-level property sustained by enhanced glycolysis and mitochondrial metabolic remodeling

Systems Biology holds that complex cellular functions are generated as system-level properties endowed with robustness, each involving large networks of molecular determinants, generally identified by omics analyses. In this paper we describe four basic cancer cell properties, that can easily be inv...

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Bibliographic Details
Main Authors: Lilia eAlberghina, Daniela eGaglio, Cecilia eGelfi, Rosa Maria Moresco, Giancarlo eMauri, Paola eBertolazzi, Cristina eMessa, Maria Carla Gilardi, Ferdinando eChiaradonna, Marco eVanoni
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-09-01
Series:Frontiers in Physiology
Subjects:
Metabolism
Systems Biology
Mitochondrial dysfunction
cancer research
emergent properties
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00362/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphys.2012.00362/full

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