Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Plasma-derived extracellular vesicles from Plasmodium vivax patients signal spleen fibroblasts via NF-kB facilitating parasite cytoadherence

Extracellular vesicles (EVs) in plasma can affect pathogenesis of parasites, but details remain unclear. Here, Toda et al. characterize plasma-derived EVs from Plasmodium vivax patients and show that PvEVs are preferentially taken up by human spleen fibroblasts, facilitating parasite cytoadherence.

Bibliographic Details
Main Authors: Haruka Toda, Miriam Diaz-Varela, Joan Segui-Barber, Wanlapa Roobsoong, Barbara Baro, Susana Garcia-Silva, Alicia Galiano, Melisa Gualdrón-López, Anne C. G. Almeida, Marcelo A. M. Brito, Gisely Cardoso de Melo, Iris Aparici-Herraiz, Carlos Castro-Cavadía, Wuelton Marcelo Monteiro, Eva Borràs, Eduard Sabidó, Igor C. Almeida, Jakub Chojnacki, Javier Martinez-Picado, Maria Calvo, Pilar Armengol, Jaime Carmona-Fonseca, Maria Fernanda Yasnot, Ricardo Lauzurica, Antonio Marcilla, Hector Peinado, Mary R. Galinski, Marcus V. G. Lacerda, Jetsumon Sattabongkot, Carmen Fernandez-Becerra, Hernando A. del Portillo
Format: Article
Language:English
Published: Nature Publishing Group 2020-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-16337-y

Internet

https://doi.org/10.1038/s41467-020-16337-y

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