Integrated conformational and lipid-sensing regulation of endosomal ArfGEF BRAG2.
The mechanisms whereby guanine nucleotide exchange factors (GEFs) coordinate their subcellular targeting to their activation of small GTPases remain poorly understood. Here we analyzed how membranes control the efficiency of human BRAG2, an ArfGEF involved in receptor endocytosis, Wnt signaling, and...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2013-09-01
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| Series: | PLoS Biology |
| Online Access: | http://europepmc.org/articles/PMC3769224?pdf=render |