Structure-Guided Mechanisms Behind the Metabolism of 2,4,6-Trinitrotoluene by Glutathione Transferases U25 and U24 That Lead to Alternate Product Distribution

Structure-Guided Mechanisms Behind the Metabolism of 2,4,6-Trinitrotoluene by Glutathione Transferases U25 and U24 That Lead to Alternate Product Distribution

The explosive xenobiotic 2,4,6-trinitrotoluene (TNT) is a major worldwide environmental pollutant and its persistence in the environment presents health and environmental concerns. The chemical structure of TNT dictates that biological detoxification pathways follow predominantly reductive transform...

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Bibliographic Details
Main Authors: Kyriakos Tzafestas, Laziana Ahmad, M. Paulina Dani, Gideon Grogan, Elizabeth L. Rylott, Neil C. Bruce
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-12-01
Series:Frontiers in Plant Science
Subjects:
2,4,6-trinitrotoluene
TNT
Arabidopsis
glutathione transferase
GST
detoxification
Online Access:https://www.frontiersin.org/article/10.3389/fpls.2018.01846/full

Internet

https://www.frontiersin.org/article/10.3389/fpls.2018.01846/full

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