Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder

Transcriptome analysis and functional characterization of cerebral organoids in bipolar disorder

Abstract Background Reprogramming human induced pluripotent stem cells (iPSCs) from somatic cells and generating three-dimensional brain organoids from these iPSCs provide access to live human neuronal tissue with disease-specific genetic backgrounds. Methods Cerebral organoids were generated from i...

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Bibliographic Details
Main Authors: Annie Kathuria, Kara Lopez-Lengowski, Magdalena Vater, Donna McPhie, Bruce M. Cohen, Rakesh Karmacharya
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Genome Medicine
Subjects:
iPSC
Organoid
Bipolar disorder
Endoplasmic reticulum
MAM
NCAN
Online Access:http://link.springer.com/article/10.1186/s13073-020-00733-6

Internet

http://link.springer.com/article/10.1186/s13073-020-00733-6

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