Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression.

Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression.

The proliferative B-13 pancreatic cell line is unique in its ability to generate functional hepatocyte-like (B-13/H) cells in response to exposure to glucocorticoid. In these studies, quantitatively comparable hepatic levels of liver-specific and liver-enriched transcription factor and hepatocyte de...

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Bibliographic Details
Main Authors: Emma A Fairhall, Michelle A Charles, Philip M E Probert, Karen Wallace, Jennifer Gibb, Chandni Ravindan, Martin Soloman, Matthew C Wright
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4782989?pdf=render

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http://europepmc.org/articles/PMC4782989?pdf=render

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