A plant-derived morphinan as a novel lead compound active against malaria liver stages.
BACKGROUND: The global spread of multidrug-resistant malaria parasites has led to an urgent need for new chemotherapeutic agents. Drug discovery is primarily directed to the asexual blood stages, and few drugs that are effective against the obligatory liver stages, from which the pathogenic blood in...
Main Authors: | , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2006-12-01
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Series: | PLoS Medicine |
Online Access: | http://europepmc.org/articles/PMC1716192?pdf=render |