A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

A multifunctional human monoclonal neutralizing antibody that targets a unique conserved epitope on influenza HA

Broadly neutralizing antibodies are potential therapeutics and can aid rational vaccine development. Here, the authors show that the human monoclonal antibody H3v-47 recognizes a highly conserved epitope in HA of H3N2 viruses, inhibits virus replication by blocking egress and other mechanisms, and p...

Full description

Bibliographic Details
Main Authors: Sandhya Bangaru, Heng Zhang, Iuliia M. Gilchuk, Thomas G. Voss, Ryan P. Irving, Pavlo Gilchuk, Pranathi Matta, Xueyong Zhu, Shanshan Lang, Travis Nieusma, Juergen A. Richt, Randy A. Albrecht, Hillary A. Vanderven, Robin Bombardi, Stephen J. Kent, Andrew B. Ward, Ian A. Wilson, James E. Crowe
Format: Article
Language:English
Published: Nature Publishing Group 2018-07-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04704-9

Internet

https://doi.org/10.1038/s41467-018-04704-9

Similar Items