Specific Sialoforms Required for the Immune Suppressive Activity of Human Soluble CD52

Specific Sialoforms Required for the Immune Suppressive Activity of Human Soluble CD52

Human CD52 is a small glycopeptide (12 amino acid residues) with one N-linked glycosylation site at asparagine 3 (Asn3) and several potential O-glycosylation serine/threonine sites. Soluble CD52 is released from the surface of activated T cells and mediates immune suppression via its glycan moiety....

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Bibliographic Details
Main Authors: Abdulrahman M. Shathili, Esther Bandala-Sanchez, Alan John, Ethan D. Goddard-Borger, Morten Thaysen-Andersen, Arun V. Everest-Dass, Timothy E. Adams, Leonard C. Harrison, Nicolle H. Packer
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Immunology
Subjects:
CD52
immune suppression
glycan structure
analysis
tetra-antennary
α-2,3 sialylation
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01967/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.01967/full

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