Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease

Phosphate stimulates myotube atrophy through autophagy activation: evidence of hyperphosphatemia contributing to skeletal muscle wasting in chronic kidney disease

Abstract Background Accelerated muscle atrophy is associated with a three-fold increase in mortality in chronic kidney disease (CKD) patients. It is suggested that hyperphosphatemia might contribute to muscle wasting, but the underlying mechanisms remain unclear. Although evidence indicates that aut...

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Bibliographic Details
Main Authors: Yue-yue Zhang, Man Yang, Jin-fang Bao, Li-jie Gu, Hong-lei Yu, Wei-jie Yuan
Format: Article
Language:English
Published: BMC 2018-02-01
Series:BMC Nephrology
Subjects:
Hyperphosphatemia
Autophagy
Muscle wasting
Cell atrophy
Chronic kidney disease
Online Access:http://link.springer.com/article/10.1186/s12882-018-0836-2

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http://link.springer.com/article/10.1186/s12882-018-0836-2

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