VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids

Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis. The present study was conducted to determine the biochemical basis of PPAR-α activation by lipolysis products and their cont...

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Bibliographic Details
Main Authors: Maxwell A. Ruby, Benjamin Goldenson, Gabriela Orasanu, Thomas P. Johnston, Jorge Plutzky, Ronald M. Krauss
Format: Article
Language:English
Published: Elsevier 2010-08-01
Series:Journal of Lipid Research
Subjects:
peroxisome proliferator activated receptor
triglyceride-rich lipoprotein
lipoprotein lipase
apolipoprotein CIII
nonesterified fatty acid
very low-density lipoprotein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520370632

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http://www.sciencedirect.com/science/article/pii/S0022227520370632

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