VLDL hydrolysis by LPL activates PPAR-α through generation of unbound fatty acids
Recent evidence suggests that lipoproteins serve as circulating reservoirs of peroxisomal proliferator activated receptor (PPAR) ligands that are accessible through lipolysis. The present study was conducted to determine the biochemical basis of PPAR-α activation by lipolysis products and their cont...
Main Authors: | Maxwell A. Ruby, Benjamin Goldenson, Gabriela Orasanu, Thomas P. Johnston, Jorge Plutzky, Ronald M. Krauss |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2010-08-01
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Series: | Journal of Lipid Research |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0022227520370632 |
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