Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration

Dynasore Blocks Ferroptosis through Combined Modulation of Iron Uptake and Inhibition of Mitochondrial Respiration

Ferroptosis is a form of regulated necrosis characterized by a chain-reaction of detrimental membrane lipid peroxidation following collapse of glutathione peroxidase 4 (Gpx4) activity. This lipid peroxidation is catalyzed by labile ferric iron. Therefore, iron import mediated via transferrin recepto...

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Bibliographic Details
Main Authors: Laura Prieto Clemente, Malena Rabenau, Stephan Tang, Josefina Stanka, Eileen Cors, Jenny Stroh, Carsten Culmsee, Silvia von Karstedt
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Cells
Subjects:
ferroptosis
radical scavenger
dynasore
Online Access:https://www.mdpi.com/2073-4409/9/10/2259

Internet

https://www.mdpi.com/2073-4409/9/10/2259

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