Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice

Reconstituted HDL (Milano) Treatment Efficaciously Reverses Heart Failure with Preserved Ejection Fraction in Mice

Heart failure with preserved ejection fraction (HFpEF) represents a major unmet therapeutic need. This study investigated whether feeding coconut oil (CC diet) for 26 weeks in female C57BL/6N mice induces HFpEF and evaluated the effect of reconstituted high-density lipoprotein (HDL)<sub>Milano...

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Bibliographic Details
Main Authors: Mudit Mishra, Ilayaraja Muthuramu, Joseph Pierre Aboumsallem, Herman Kempen, Bart De Geest
Format: Article
Language:English
Published: MDPI AG 2018-10-01
Series:International Journal of Molecular Sciences
Subjects:
Reconstituted HDL
cardiac hypertrophy
coconut oil
heart failure
HFpEF
cardiac function
exercise capacity
lactate
acetyl-coenzyme A carboxylase
transforming growth factor-β1
Online Access:https://www.mdpi.com/1422-0067/19/11/3399

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https://www.mdpi.com/1422-0067/19/11/3399

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