Association of Polymorphisms in T-Cell Activation Costimulatory/Inhibitory Signal Genes With Allograft Kidney Rejection Risk

Association of Polymorphisms in T-Cell Activation Costimulatory/Inhibitory Signal Genes With Allograft Kidney Rejection Risk

The genes CD28, CD86 and CTLA-4 conform the costimulatory (CD28-CD86) or inhibitory (CTLA-4-CD86) signal in T-cell activation. T-cell immune response has a critical role in allograft rejection, and single nucleotide polymorphisms (SNPs) located in these genes have been widely analyzed with controver...

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Bibliographic Details
Main Authors: Jose Luis Santiago, Luis Sánchez-Pérez, Isabel Pérez-Flores, Maria Angeles Moreno de la Higuera, Natividad Calvo Romero, Javier Querol-García, Elena Urcelay, Ana Isabel Sánchez-Fructuoso
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Immunology
Subjects:
allograft rejection
Banff classification
cytotoxic T-lymphocyte associated protein 4
kidney transplantation
polymorphism
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.650979/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.650979/full

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