Mitosis gives a brief window of opportunity for a change in gene transcription.

Cell differentiation is remarkably stable but can be reversed by somatic cell nuclear transfer, cell fusion, and iPS. Nuclear transfer to amphibian oocytes provides a special opportunity to test transcriptional reprogramming without cell division. We show here that, after nuclear transfer to amphibi...

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Bibliographic Details
Main Authors: Richard P Halley-Stott, Jerome Jullien, Vincent Pasque, John Gurdon
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-07-01
Series:PLoS Biology
Online Access:http://europepmc.org/articles/PMC4114836?pdf=render