Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer

Methylglyoxal-Mediated Stress Correlates with High Metabolic Activity and Promotes Tumor Growth in Colorectal Cancer

Cancer cells generally rely on aerobic glycolysis as a major source of energy. Methylglyoxal (MG), a dicarbonyl compound that is produced as a side product during glycolysis, is highly reactive and induces the formation of advanced glycation end-products that are implicated in several pathologies in...

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Bibliographic Details
Main Authors: Barbara Chiavarina, Marie-Julie Nokin, Justine Bellier, Florence Durieux, Noëlla Bletard, Félicie Sherer, Pierre Lovinfosse, Olivier Peulen, Laurine Verset, Romain Dehon, Pieter Demetter, Andrei Turtoi, Koji Uchida, Serge Goldman, Roland Hustinx, Philippe Delvenne, Vincent Castronovo, Akeila Bellahcène
Format: Article
Language:English
Published: MDPI AG 2017-01-01
Series:International Journal of Molecular Sciences
Subjects:
methylglyoxal
colorectal cancer
MG-adducts
glyoxalase 1
18F-Fluorodeoxyglucose (18F-FDG)
Online Access:http://www.mdpi.com/1422-0067/18/1/213

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http://www.mdpi.com/1422-0067/18/1/213

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