Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

Activation of Wnt signaling by chemically induced dimerization of LRP5 disrupts cellular homeostasis.

Wnt signaling is crucial for a variety of biological processes, including body axis formation, planar polarity, stem cell maintenance and cellular differentiation. Therefore, targeted manipulation of Wnt signaling in vivo would be extremely useful. By applying chemical inducer of dimerization (CID)...

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Bibliographic Details
Main Authors: Payam Shahi, Dongsu Park, Adam C Pond, Mamatha Seethammagari, Shin-Heng Chiou, Kyucheol Cho, Julienne L Carstens, William K Decker, Pierre D McCrea, Michael M Ittmann, Jeffrey M Rosen, David M Spencer
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3267738?pdf=render

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http://europepmc.org/articles/PMC3267738?pdf=render

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