Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease

Ileal Inflammation May Trigger the Development of GP2-Specific Pancreatic Autoantibodies in Patients with Crohn’s Disease

Why zymogen glycoprotein 2 (GP2), the Crohn’s disease (CD)-specific pancreatic autoantigen, is the major target of humoral autoimmunity in inflammatory bowel diseases (IBD) is uknown. Recent evidence demonstrates that GP2 is also present on the apical surface of microfold (M) intestinal cells. As th...

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Bibliographic Details
Main Authors: Polychronis Pavlidis, Ourania Romanidou, Dirk Roggenbuck, Maria G. Mytilinaiou, Faris Al-Sulttan, Christos Liaskos, Daniel S. Smyk, Andreas L. Koutsoumpas, Eirini I. Rigopoulou, Karsten Conrad, Alastair Forbes, Dimitrios P. Bogdanos
Format: Article
Language:English
Published: Hindawi Limited 2012-01-01
Series:Clinical and Developmental Immunology
Online Access:http://dx.doi.org/10.1155/2012/640835

Internet

http://dx.doi.org/10.1155/2012/640835

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