Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

Expression and Localization of Paneth Cells and Their α-Defensins in the Small Intestine of Adult Mouse

Paneth cells contribute to intestinal innate immunity by sensing bacteria and secreting α-defensin. In Institute of Cancer Research (ICR) mice, α-defensin termed cryptdin (Crp) in Paneth cells consists of six major isoforms, Crp1 to 6. Despite accumulating evidences that α-defensin functions in cont...

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Bibliographic Details
Main Authors: Kiminori Nakamura, Yuki Yokoi, Rie Fukaya, Shuya Ohira, Ryuga Shinozaki, Takuto Nishida, Mani Kikuchi, Tokiyoshi Ayabe
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-10-01
Series:Frontiers in Immunology
Subjects:
Paneth cell
alpha-defensin
cryptdin
Institute of Cancer Research mouse
innate immunity
germ-free mouse
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2020.570296/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2020.570296/full

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