Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis

Suppression of the Peripheral Immune System Limits the Central Immune Response Following Cuprizone-Feeding: Relevance to Modelling Multiple Sclerosis

Cuprizone (CPZ) preferentially affects oligodendrocytes (OLG), resulting in demyelination. To investigate whether central oligodendrocytosis and gliosis triggered an adaptive immune response, the impact of combining a standard (0.2%) or low (0.1%) dose of ingested CPZ with disruption of the blood br...

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Bibliographic Details
Main Authors: Monokesh K. Sen, Mohammed S. M. Almuslehi, Erika Gyengesi, Simon J. Myers, Peter J. Shortland, David A. Mahns, Jens R. Coorssen
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Cells
Subjects:
inside-out
outside-in
oligodendrocytosis
demyelination
gliosis
histology
top-down proteomics
bioinformatics
mitochondria
Online Access:https://www.mdpi.com/2073-4409/8/11/1314

Internet

https://www.mdpi.com/2073-4409/8/11/1314

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