Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G-protein-coupled receptors

Isolation of the bioactive peptides CCHamide-1 and CCHamide-2 from Drosophila and their putative role in appetite regulation as ligands for G-protein-coupled receptors

There are many orphan G-protein-coupled receptors (GPCRs) for which ligands have not yet been identified. One such GPCR is the bombesin receptor subtype 3 (BRS-3). BRS-3 plays a role in the onset of diabetes and obesity. GPCRs in invertebrates are similar to those in vertebrates. Two Drosophila GPCR...

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Bibliographic Details
Main Authors: Takanori eIda, Tomoko eTakahashi, Hatsumi eTominaga, Takahiro eSato, Hiroko eSano, Kazuhiko eKume, Mamiko eOzaki, Tetsutaro eHiraguchi, Hajime eShiotani, Saki eTerajima, Yuki eNakamura, Kenji eMori, Morikatsu eYoshida, Johji eKato, Noboru eMurakami, Mikiya eMiyazato, Kenji eKangawa, Masayasu eKojima
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Endocrinology
Subjects:
Drosophila
GPCR
novel bioactive peptide
CCHamide
bombesin receptor subtype 3
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00177/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00177/full

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