Immunization of Experimental Dogs With Salivary Proteins From Lutzomyia longipalpis, Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against Leishmania infantum

Immunization of Experimental Dogs With Salivary Proteins From Lutzomyia longipalpis, Using DNA and Recombinant Canarypox Virus Induces Immune Responses Consistent With Protection Against Leishmania infantum

Metacyclic Leishmania promastigotes are transmitted by sand flies that inject parasites and saliva into the host's skin. Previous studies have demonstrated that DNA plasmids encoding Lutzomyia longipalpis salivary proteins LJM17 and LJL143, when used to immunize dogs, resulted in a systemic and...

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Bibliographic Details
Main Authors: Melissa Moura Costa Abbehusen, Jurema Cunha, Martha Sena Suarez, Clarissa Teixeira, Valter dos Anjos Almeida, Laís da Silva Pereira, Marcelo Bordoni, Leonardo Gil-Santana, Manuela da Silva Solcà, Deborah Bittencourt Moté Fraga, Laurent Fischer, Patricia Torres Bozza, Patricia Sampaio Tavares Veras, Jesus G. Valenzuela, Shaden Kamhawi, Bruno B. Andrade, Claudia I. Brodskyn
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Immunology
Subjects:
vaccine
sand fly
canine visceral leishmaniasis
disease vectors
salivary proteins
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2018.02558/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2018.02558/full

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