Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway

Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway

Sepsis, as life-threatening organ dysfunction caused by a dysregulated host response to infection, is characterized by the extensive release of cytokines and other mediators. Sini decoction (SND), a traditional Chinese prescription medicine, has been used clinically for the treatment of sepsis. But...

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Bibliographic Details
Main Authors: Qiuhua Chen, Junjun Liu, Wanqiu Wang, Suzi Liu, Xiaoting Yang, Mingqi Chen, Lu Cheng, Jun Lu, Tao Guo, Fengjie Huang
Format: Article
Language:English
Published: Elsevier 2019-07-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Sepsis
HUVECs
SND
Renin-angiotensin system (RAS)
MAPKs
NF-κB
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332219308200

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http://www.sciencedirect.com/science/article/pii/S0753332219308200

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