Diffusion Tensor Imaging and Chemical Exchange Saturation Transfer MRI Evaluation on the Long-Term Effects of Pulsed Focused Ultrasound and Microbubbles Blood Brain Barrier Opening in the Rat

Diffusion Tensor Imaging and Chemical Exchange Saturation Transfer MRI Evaluation on the Long-Term Effects of Pulsed Focused Ultrasound and Microbubbles Blood Brain Barrier Opening in the Rat

Blood-brain barrier opening (BBBO) with pulsed Focused Ultrasound (pFUS) and microbubbles (MB) has received increasing interest as a method for neurotherapeutics of the central nervous system. In general, conventional MRI [i.e., T2w, T2∗w, gadolinium (Gd) enhanced T1w] is used to monitor the effects...

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Bibliographic Details
Main Authors: Tsang-Wei Tu, Zsofia I. Kovacs, Maggie Sundby, Jaclyn A. Witko, Georgios Z. Papadakis, William C. Reid, Dima A. Hammoud, Joseph A. Frank
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-08-01
Series:Frontiers in Neuroscience
Subjects:
pFUS microbubble
blood brain barrier
T2∗ abnormality
DTI
CEST
FDG-PET
Online Access:https://www.frontiersin.org/article/10.3389/fnins.2020.00908/full

Internet

https://www.frontiersin.org/article/10.3389/fnins.2020.00908/full

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